Prevention & lipidsCohort study
High-Volume Physical Activity and Clinical Coronary Artery Disease Outcomes: Findings From the Cooper Center Longitudinal Study
- Prospective cohort study
- multivariable-adjusted illness-death model
Authors' conclusion
Compared with low-volume PA, high-volume PA was associated with a lower risk for all-cause mortality but a similar risk for clinical CAD. CAC was associated with an increased risk for clinical CAD regardless of the volume of PA.
Study context
- Population
- Cooper Center Longitudinal Study participants (1987–2018) linked to Medicare claims28% women
- Participants
- 26,724 participants
- Exposure
- Physical activity (PA) volume categories vs <500
- >3000n = 1,997
- Outcome
- Composite:
- CAD events (acute MI and revascularization)
- All-cause mortality
- Follow-up
- Mean 20.5 years
Main finding
As reported in the abstract
Acute MI and death by PA volume
Each group vs <500Hazard ratio (95% CI)
500-1499acute MI
0.77(0.65–0.91)
1500-2499acute MI
0.78(0.63–0.95)
>3000acute MI; no association
0.95(0.72–1.25)
>3000death
0.71(0.60–0.83)
- Acute MI events
- 811
- Composite coronary artery disease (CAD) events
- 1636
- Deaths without CAD
- 2857
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CAC (log scale) and composite CAD, high-volume PA subgroup · associated across all PA categories | 1.29 (1.16–1.44) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
- CAC (log scale) and composite CAD, high-volume PA subgroup: Pinteraction= 0.969
Original publication
High-Volume Physical Activity and Clinical Coronary Artery Disease Outcomes: Findings From the Cooper Center Longitudinal Study. Circulation. Published 21 April 2025. doi:10.1161/circulationaha.124.070335
Summarised from the published abstract; every number is checked against it