Heart failure & cardiomyopathiesCohort study
Higher Emergency Department Diuretic Dosing for Acute Heart Failure Associated With Lower Risk of Hospitalization
- Retrospective cohort study
- inverse propensity treatment weighting
- 21 emergency department (EDs)
Authors' conclusion
Use of higher-dose diuretic agents was associated with lower hospital admissions without evidence of persistent AKI.
Study context
- Population
- Adults with acute HF receiving IV diuretics in the ED, 21 EDs, 2023–2024
- Participants
- 14,983 ED encounters
- Exposure
- Medium- and high-dose vs low-dose initial ED IV diuretic
- Lown = 5,436reference
- Mediumn = 5,329
- Highn = 4,218
- Outcome
- Hospital admission or AKI
- Follow-up
- 48 hours
Main finding
As reported in the abstract
Hospital admission
Each group vs lowRisk difference (95% CI)
Medium
−2.6%(−4.4% to −0.9%)
High
−1.2%(−3.1% to −0.7%)
Observational data: associations, not effects.
Further findings
Persistent AKI at hospital discharge
- No significant differences in the higher-dose groups
Safety
| Outcome | risk difference (95% CI) | |
|---|---|---|
| AKI · 48 hours · higher with high dose | 2.9% (1.4%–4.5%) | |
| −20246Difference (linear scale) |
Original publication
Higher Emergency Department Diuretic Dosing for Acute Heart Failure Associated With Lower Risk of Hospitalization. JACC Heart Fail. Published 31 July 2026. doi:10.1016/j.jchf.2026.103235
Summarised from the published abstract; every number is checked against it