Heart failure & cardiomyopathiesCohort study
Home-based Urinary Sodium Monitoring via Point-of-Care Testing for Personalized Diuretic Titration in Heart Failure Management: The EASY-STOP study
- Prospective cohort study
- single-centre
- blinded urinary sodium analysis
Authors' conclusion
Point-of-care urinary sodium monitoring may represent a non-invasive and personalized approach to diuretic titration in HF management.
Study context
- Population
- Euvolaemic heart failure (HF) patients on stable guideline-directed medical therapy ≥3 months and maintenance loop diuretic (≥20 mg furosemide equivalent daily)62 down-titrations
- Participants
- 50 patients
- Exposure
- Successful vs unsuccessful loop diuretic down-titration
- Successful down-titrationn = 34
- Outcome
- Successful diuretic down-titration (remaining congestion-free) guided by ambulatory point-of-care urinary sodium monitoring
Main finding
As reported in the abstract
Successful down-titration and change in first-void urinary sodium
| Group | Value | First-void urinary sodium before–after down-titration |
|---|---|---|
| Successful down-titration | 55% | 53-74 mmol/L, p < 0.001 |
| Reinitiation | 56-58 mmol/L, p = 0.331 |
- 10 mmol/L increase predicting successful down-titration: sensitivity
- 79.4%
- 10 mmol/L increase predicting successful down-titration: specificity
- 78.6%
- 10 mmol/L increase predicting successful down-titration: AUC
- 0.851
Observational data: associations, not effects.
Original publication
Home-based Urinary Sodium Monitoring via Point-of-Care Testing for Personalized Diuretic Titration in Heart Failure Management: The EASY-STOP study. Eur J Heart Fail. Published 19 May 2025. doi:10.1002/ejhf.3693
Summarised from the published abstract; every number is checked against it