Heart failure & cardiomyopathiesCohort study
Hospitalized Advanced Heart Failure With Preserved vs Reduced Left Ventricular Ejection Fraction
- Registry-based cohort study (analysis of the global REPORT-HF registry)
Authors' conclusion
Hospitalized patients with advanced HF and preserved LVEF had similarly adverse outcomes as those with reduced LVEF.
Study context
- Population
- Hospitalized patients with advanced heart failure (HF) (previously diagnosed HF, NYHA III/IV before admission, ≥1 HF hospitalization in preceding 12 months) in the REPORT-HF registryadvanced HF of 18,553 acute HF
- Participants
- 3,397 patients
- Exposure
- Advanced HF across left ventricular ejection fraction (LVEF) categories, world regions and country income
Main finding
As reported in the abstract
Adjusted 1-year mortality and 1-year HF hospitalization by LVEF · 1 year
- Adjusted 1-year mortality risk did not differ among LVEF subgroups
- all P > 0.05
- 1-year HF hospitalization rate did not differ among LVEF subgroups
- P = 0.56
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| 1-year mortality by world region · lowest and highest regions | Eastern Europe 23% · Southeast Asia 37% |
| 1-year mortality by country income | Lower-middle-income 34% · Upper-middle-income 26% · High-income 27% |
- 1-year mortality by country income — Higher mortality in lower-middle-income countries; fewer beta-blockers and HF devices
- P = 0.018
Original publication
Hospitalized Advanced Heart Failure With Preserved vs Reduced Left Ventricular Ejection Fraction. JACC Heart Fail. Published 6 November 2024. doi:10.1016/j.jchf.2024.09.009
Summarised from the published abstract; every number is checked against it