Valvular & structural heart disease
How can progression be predicted in patients with mild to moderate aortic valve stenosis?
Authors' conclusion
AoV Doppler-derived dP/dt above 600 mmHg/s was associated with risk of AS progression to the severe stage in patients with mild to moderate AS.
Study context
- Population
- Patients with mild to moderate aortic stenosis (AS) (Vmax between 2 and 4 m/s) by echocardiographic criteria
- Participants
- 481 patients
- Exposure
- Mild AS vs Moderate AS
- Mild ASn = 404
- Moderate ASn = 77
- Outcome
- Progression to severe AS
- Follow-up
- Median 2.7 years
Methodological detailsAoV dP/dt measured as time for AoV jet velocity to rise from 1 m/s to 2 m/s
- AoV dP/dt measured as time for AoV jet velocity to rise from 1 m/s to 2 m/s
Main finding
As reported in the abstract
Estimate (95% CI)P value
AoV calcium score (initial)
aOR 1.79(1.18–2.73)
P = 0.006AoV Doppler-derived dP/dt
aOR 1.52 per 100 mmHg/s higher dP/dt(1.10–2.05)
P = 0.012Per 100 mmHg/s higher dP/dt, as printed
- AoV Doppler-derived dP/dt predicting progression to severe AS, AUC
- 0.868
- dP/dt cut-off value
- 600 mmHg/s
Observational data: associations, not effects.
Original publication
How can progression be predicted in patients with mild to moderate aortic valve stenosis? Eur Heart J Cardiovasc Imaging. Published 9 May 2023. doi:10.
Summarised from the published abstract; every number is checked against it