Cardio-oncology & otherCohort study
Hybrid Magnetic Resonance Positron Emission Tomography Is Associated With Cardiac-Related Outcomes in Cardiac Sarcoidosis
- Cohort study
Authors' conclusion
Hybrid MR/PET image-based classification of CS was statistically associated with clinical outcomes in CS. TNMRmax had modest sensitivity and specificity for quantifying the imaging-based classification MR(+)PET(+)FOCAL and was associated with outcomes.
Study context
- Population
- Patients with suspected cardiac sarcoidosis undergoing hybrid magnetic resonance (MR)/PET imaging
- Participants
- 148 patients
- Exposure
- MR5.7%PETFOCAL vs all other imaging classifications
- Outcome
- Cardiac arrest, VT or secondary prevention implantable cardioverter-defibrillator (ICD)
- Follow-up
- Before the end of the study
Main finding
As reported in the abstract
Odds ratio
9.2
95% CI 3.0–28.7
P = 0.0001
MR(+)5.7%PET(+)FOCAL vs All other imaging classifications
OR 9.2 (95% CI 3.0–28.7); P = 0.0001
Observational data: associations, not effects.
Secondary outcomes
TNMRmax discrimination
- AUC, MR(+)PET(+)FOCAL vs non-MR(+)PET(+)FOCAL
- 0.90
- AUC, reaching vs not reaching clinical endpoint
- 0.77
Original publication
Hybrid Magnetic Resonance Positron Emission Tomography Is Associated With Cardiac-Related Outcomes in Cardiac Sarcoidosis. JACC Cardiovasc Imaging. Published 31 January 2024. doi:10.1016/j.jcmg.2023.11.010
Summarised from the published abstract; every number is checked against it