Valvular & structural heart diseaseCohort study
Hyperglycaemia and genetic susceptibility in relation to incident degenerative aortic valve stenosis
- Prospective cohort study
- population-based
Authors' conclusion
Prediabetes, in addition to diabetes, was associated with an increased risk of AS and AS-related events, independent of a genetic risk score for AS.
Study context
- Population
- UK Biobank participantsUK Biobank
- Participants
- 461,017 participants
- Exposure
- Prediabetes and T2DM vs normoglycaemia
- Outcome
- Incident degenerative AS
- Follow-up
- Median 14.3 years
Main finding
As reported in the abstract
Incident AS
Each group vs normoglycaemiaAdjusted hazard ratio (95% CI)
Prediabetes
1.21(1.13–1.30)
Type 2 diabetes
1.66(1.52–1.80)
- Incident AS cases
- 5307
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Estimate | |
|---|---|---|
| AS-related events (AS-related intervention or death due to AS) — Prediabetes vs Normoglycaemia | adjusted HR 1.26 (95% CI 1.13–1.41) | |
| AS-related events (AS-related intervention or death due to AS) — Type 2 diabetes vs Normoglycaemia | adjusted HR 1.60 (95% CI 1.40–1.83) | |
| Joint association with genetic risk: diabetes and high genetic risk — Diabetes and high genetic risk vs Normoglycaemia · AS | HR 3.25 (95% CI 2.82–3.74) | |
| Joint association with genetic risk: diabetes and high genetic risk — Diabetes and high genetic risk vs Normoglycaemia · AS-related events | HR 3.79 (95% CI 3.05–4.72) | |
| 0.20.5125Ratio (log scale) |
- AS-related events (AS-related intervention or death due to AS) — AS-related events
- 2209
Joint association with genetic risk: diabetes and high genetic risk
- Prediabetes or diabetes had higher risk of AS and AS-related events regardless of genetic risk
Original publication
Hyperglycaemia and genetic susceptibility in relation to incident degenerative aortic valve stenosis. Eur J Prev Cardiol. Published 20 June 2025. doi:10.1093/eurjpc/zwaf355
Summarised from the published abstract; every number is checked against it