HypertensionCohort study
Hypertension and cardiometabolic disorders appear 5–10 years earlier in women with pre-eclampsia
- Retrospective cohort study
Authors' conclusion
Cardiovascular risk factors occur almost a decade earlier in former pre-eclamptic women compared to women after normotensive gestation, predominantly, but not exclusively, due to the early and accelerated development of hypertension.
Study context
- Population
- Parous women up to 30 years postpartum
- Participants
- 1,040 vs 518
- Exposure
- Pre-eclampsia vs normotensive gestation
- Pre-eclampsian = 1,040
- Normotensive gestationn = 518reference
- Outcome
- Age-related prevalence of CV risk factors (hypertension, DM, hypercholesterolaemia, obesity, insulin resistance, CKD, micro-albuminuria)
- Follow-up
- Up to 30 years postpartum
Main finding
As reported in the abstract
Hypertension, DM or hypercholesterolaemia (either/combined)
Adjusted hazard ratio
2.6
95% CI 2.1–3.2
By group
Pre-eclampsia vs Normotensive gestation
aHR 2.6 (95% CI 2.1–3.2)
- Risk factors occurred on average earlier after pre-eclampsia
- 8 years
Observational data: associations, not effects.
Further findings
Hypertension prevalence with ageing
- Steeper increase after pre-eclampsia
- P for interaction = 0.044
- Cumulative hypertension proportion exceeded 10% cut-off for cardiovascular (CV) risk assessment from 35 years onwards after pre-eclampsia
Original publication
Hypertension and cardiometabolic disorders appear 5–10 years earlier in women with pre-eclampsia. Eur J Prev Cardiol. Published 23 April 2025. doi:10.1093/eurjpc/zwaf187
Summarised from the published abstract; every number is checked against it