Cardio-oncology & otherCohort study
Hypertensive Disorders of Pregnancy and Premature Cardiovascular Disease in a Diverse Cohort of Young US Women
- Retrospective cohort study
- multicentre
- external replication cohort
Authors' conclusion
In a diverse, national sample of young US women, HDP were a significant marker of premature CVD risk, even in the absence of prepregnancy cardiometabolic risk factors.
Study context
- Population
- Women with longitudinal pregnancy and postpartum data, All of Us research program (>50 US health systems), 2007–2022replication cohort n=56,549
- Participants
- 17,357 women
- Exposure
- Hypertensive disorders of pregnancy (HDP) vs no HDP
Main finding
CVD · median 4.6 years
Adjusted hazard ratio
1.82
95% CI 1.49–2.22
HDP vs No HDP
aHR 1.82 (95% CI 1.49–2.22)
As reported in the abstract
- HDP occurred in pregnancies
- 2098 (12%)
- Women who developed cardiovascular disease (CVD)
- 701
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| CVD, by prepregnancy cardiometabolic risk factors (subgroup) — HDP vs No HDP · without risk factors | 2.06 (1.55–2.74) | |
| CVD, by prepregnancy cardiometabolic risk factors (subgroup) — HDP vs No HDP · with risk factors | 1.33 (1.00–1.77) | |
| Composite CVD, external replication cohort · n=56 549 | 2.62 (2.17–3.16) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Hypertensive Disorders of Pregnancy and Premature Cardiovascular Disease in a Diverse Cohort of Young US Women. Circulation. Published 8 November 2025. doi:10.1161/circulationaha.125.078057
Summarised from the published abstract; every number is checked against it