Heart failure & cardiomyopathies
Hypertrophic cardiomyopathy management: a systematic review of the clinical practice guidelines and recommendations
Authors' conclusion
Contemporary guidelines for HCM achieve consensus across a broad range of criteria and recommendations concerning diagnosis and management. However, variations in the approach towards risk assessment for SCD exist between the guidelines. There are also more subtle differences concerning diagnostic criteria and the utility of late gadolinium enhancement for risk stratification, which will likely evolve as the evidence-base broadens.
Study context
- Population
- Clinical practice guidelines for the diagnosis and management of hypertrophic cardiomyopathy (HCM) in adultsguidelines on the diagnosis and management of HCM identified, all robustly developed (AGREE rigour of development score ≥50%)
- Participants
- three guidelines
- Comparison
- Consensus and discrepant areas in the clinical practice guidelines
- Outcome
- Areas of consensus
Methodological detailsEnglish language guidelines and recommendations, MEDLINE and EMBASE databases, guidelines published in the last 10 years
- English language guidelines and recommendations
- MEDLINE and EMBASE databases
- Guidelines published in the last 10 years
Pooled result
As reported in the abstract
- Broad consensus on echocardiographic recommendations, the medical and invasive management of HCM, the application of genetic testing and family screening, and exercise and reproductive recommendations in HCM
Further pooled results
Areas of variability
- Variability in the definition and diagnostic criteria for HCM, cardiovascular magnetic resonance imaging recommendations, and assessment of sudden cardiac death (SCD) risk and prevention strategies
Cardiac myosin ATPase inhibitors
- No recommendations on the use of cardiac myosin ATPase inhibitors in the Japanese Circulation Society (JCS)/Japanese Heart Failure Society (JHFS) guidelines, due to them being older
Original publication
Hypertrophic cardiomyopathy management: a systematic review of the clinical practice guidelines and recommendations. Eur Heart J Qual Care Clin Outcomes. Published 2 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it