Identification of capillary rarefaction using intracoronary wave intensity analysis with resultant prognostic implications for cardiac allograft patients
An erratum to this article was published (Eur Heart J, 21 Jun 2018 ↗)
Main finding · Angiographic CAV by BDW sizeResult — go to the resultHazard ratio 2.89 95% CI 1.12–7.39Authors' conclusion
Within cardiac transplant patients, WIA is able to quantify the earliest histological changes of CAV and can predict clinical and angiographic outcomes.
Study context
- Population
- Cardiac allograft recipients with unobstructed coronary arteries and normal left ventricular (LV) function46 with adequate measurements
- Participants
- 52 recipients
- Exposure
- Smaller vs larger backward decompression wave on intracoronary wave intensity analysis (WIA)
- Outcome
- Angiographic cardiac allograft vasculopathy (CAV)
- Follow-up
- Mean 9.3 ± 5.2 years
Methodological details2 lost to follow-up, 1-3 yearly screening angiography
- 2 lost to follow-up
- 1-3 yearly screening angiography
Main finding
Angiographic CAV by BDW size
Hazard ratio
2.89
95% CI 1.12–7.39
P = 0.03
Smaller vs larger backward decompression wave (BDW) on intracoronary WIA
HR 2.89 (95% CI 1.12–7.39); P = 0.03
As reported in the abstract
Observational data: associations, not effects.
Further findings
Correlation with capillary density (RV biopsy subgroup, n = 15)
- Coronary flow reserve (CFR) vs capillary density, r
- 0.52 (P = 0.048)
- Backward decompression wave (BDW) vs capillary density, r
- −0.65 (P < 0.01)
Index BDW and clinical CAV events / disease severity
- Index BDW lower in those with clinical CAV events
- P = 0.04
- Index BDW lower in those with more severe disease
- P = 0.01
Original publication
Identification of capillary rarefaction using intracoronary wave intensity analysis with resultant prognostic implications for cardiac allograft patients. Eur Heart J. Published 13 December 2017. doi:10.
Summarised from the published abstract; every number is checked against it