Arrhythmias & electrophysiology

Identification of Human Ventricular Tachycardia Demarcated by Fixed Lines of Conduction Block in a 3-Dimensional Hyperboloid Circuit

CirculationPublished Mechanistic study

Authors' conclusion

The majority of VT circuit boundaries can be identified as fixed LOB from intrinsic or paced activation during sinus rhythm.

Study context

Population
Patients undergoing catheter ablation for scar-related ventricular tachycardia (VT) (42% nonischemic cardiomyopathy)175 VT activation maps
Participants
106 patients
Outcome
Correlation of lines of conduction block (LOB) during baseline rhythm or pacing with VT isthmus boundaries
Methodological detailsmulticentre (3 centres)
  • Multicentre (3 centres)

Main finding

As reported in the abstract

Deceleration zones with overt LOB during baseline rhythm (of 202)
47%
Concealed LOB unmasked by differential pacing in deceleration zones without overt LOB (n=38)
84%
Lateral boundaries colocalized with LOB in 2D VT (152 maps: 2D=53, 3D=99)
69%
Depth boundary colocalized with LOB in 3D VT
79%
Isthmus boundaries identifiable as fixed LOB during baseline rhythm or differential pacing
74%

Original publication

Identification of Human Ventricular Tachycardia Demarcated by Fixed Lines of Conduction Block in a 3-Dimensional Hyperboloid Circuit. Circulation. Published 28 August 2023. doi:10.1161/circulationaha.123.065525

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