Heart failure & cardiomyopathiesCohort study
Identification of Subclinical Heart Failure With Preserved Ejection Fraction in Patients With Symptomatic Atrial Fibrillation
- Prospective cohort study
- consecutive recruitment
- invasive haemodynamics
Authors' conclusion
Subclinical HFpEF is common in AF ablation patients and is characterized by a LA cardiomyopathy, decreased cardiopulmonary reserve and increased symptom burden.
Study context
- Population
- Consecutive patients with symptomatic atrial fibrillation (AF) undergoing ablation, without overt clinical HF
- Participants
- 120 patients
- Exposure
- Heart Failure with Preserved Ejection Fraction (HFpEF) vs early HFpEF vs no HFpEF
- HFpEFn = 57
- Early HFpEFn = 31
- No HFpEFn = 32reference
- Outcome
- Prevalence of subclinical HFpEF by invasive LAP
Main finding
As reported in the abstract
Prevalence of subclinical HFpEF
Observational data: associations, not effects.
Further findings
LA compliance
- Lower LA compliance with HFpEF and early HFpEF vs no HFpEF
- P < 0.001
LA emptying fraction, LA voltage, VO2peak, AF symptom burden
- Decreased LA emptying fraction with HFpEF and early HFpEF vs no HFpEF
- P = 0.004
- Decreased LA voltage with HFpEF and early HFpEF vs no HFpEF
- P = 0.001
- Decreased VO2peak with HFpEF and early HFpEF vs no HFpEF
- P < 0.001
- Increased AF symptom burden with HFpEF and early HFpEF vs no HFpEF
- P = 0.002
Original publication
Identification of Subclinical Heart Failure With Preserved Ejection Fraction in Patients With Symptomatic Atrial Fibrillation. JACC Heart Fail. Published 6 September 2023. doi:10.1016/j.jchf.2023.07.019
Summarised from the published abstract; every number is checked against it