Arrhythmias & electrophysiologyMechanistic study
Identifying extra pulmonary vein targets for persistent atrial fibrillation ablation: bridging advanced and conventional mapping techniques
- Mechanistic study
Charge density mapping (CDM) and electroanatomic voltage mapping during atrial fibrillation (AF) and sinus rhythm with multiple pacing protocols; comparison via a left atrium statistical shape model
Authors' conclusion
Mapping techniques during paced rhythms do not reliably correspond with regions of CDM-identified propagation patterns in persistent AF. However, these propagation patterns are consistently observed in two specific anatomical regions, suggesting a predisposition to abnormal electrophysiological properties.
Study context
- Population
- Patients undergoing de novo ablation of persistent AF
- Participants
- 22 patients
- Comparison
- CDM-identified propagation patterns vs low-voltage areas (LVAs) and slow conduction velocity (CV) regions on contact mapping
- Outcome
- Correspondence of left atrial regions containing CDM-identified pivoting and rotational propagation patterns during AF with conventional contact mapping (LVAs, slow CV)
Main finding
As reported in the abstract
CV mapping during AF correlated with pivoting-pattern regions (ρ)
−0.63, P < 0.0001
CV mapping during AF correlated with rotational-pattern regions (ρ)
−0.54, P < 0.0001
Original publication
Summarised from the published abstract; every number is checked against it