Identifying Patients With Prostate Cancer Who Benefit Most From Routine Cardiovascular Specialist Referral
Authors' conclusion
Uncontrolled modifiable CV risk factors may identify patients with prostate cancer who are more likely to benefit from routine CV care referral.
Study context
- Population
- Patients with prostate cancer or receiving androgen-deprivation therapy
- Participants
- 2,487 patients
- Comparison
- Routine referral to a cardiologist or internist for cardiovascular (CV) risk-factor and lifestyle modification vs no routine referral
- Primary endpoint
- Hierarchical composite of:
- CV death
- Myocardial infarction (MI)
- Stroke
- Heart failure (HF)
- Suboptimal cholesterol and systolic blood pressure (SBP) control (win ratio)
- Time to CV death
- MI
- Stroke
- HF
Methodological detailsprespecified subgroup analysis, pragmatic
- Prespecified subgroup analysis
- Pragmatic
Primary result
As reported in the abstract
Treatment effect of routine CV specialist referral by subgroup (prespecified)
Win ratio (95% CI)
Total cholesterol ≤4 mmol/Lhierarchical composite; interaction P = 0.016
1.21(0.89–1.64)
Total cholesterol >4 mmol/Lhierarchical composite; interaction P = 0.016
1.75(1.51–2.03)
Subdistribution hazard ratio (95% CI)
SBP ≥130 mm Hg or diastolic BP ≥80 mm HgCV death, MI, stroke, or HF; interaction P = 0.003
0.86(0.61–1.21)
BP <130/80 mm HgCV death, MI, stroke, or HF; interaction P = 0.003
4.85(1.65–14.26)
Participants with diabetesinteraction P = 0.054
0.53(0.24–1.15)
Participants without diabetesinteraction P = 0.054
1.25(0.88–1.78)
Original publication
Identifying Patients With Prostate Cancer Who Benefit Most From Routine Cardiovascular Specialist Referral. JACC CardioOncol. Published 30 August 2026. doi:10.
Summarised from the published abstract; every number is checked against it