Cardio-oncology & otherSecondary analysis
Identifying Patients With Prostate Cancer Who Benefit Most From Routine Cardiovascular Specialist Referral
- Secondary analysis of the RADICAL PC-2 randomised trial
- prespecified subgroup analysis
- pragmatic
Authors' conclusion
Uncontrolled modifiable CV risk factors may identify patients with prostate cancer who are more likely to benefit from routine CV care referral.
Study context
- Population
- Patients with prostate cancer or receiving androgen-deprivation therapy
- Participants
- 2,487 patients
- Comparison
- Routine referral to a cardiologist or internist for cardiovascular (CV) risk-factor and lifestyle modification vs no routine referral
- Primary endpoint
- Hierarchical composite of:
- CV death
- Myocardial infarction (MI)
- Stroke
- Heart failure (HF)
- Suboptimal cholesterol and systolic blood pressure (SBP) control (win ratio)
- Time to CV death
- MI
- Stroke
- HF
Primary result
As reported in the abstract
Treatment effect of routine CV specialist referral by subgroup (prespecified)
Win ratio (95% CI)
total cholesterol ≤4 mmol/Lhierarchical composite; interaction P = 0.016
1.21(0.89–1.64)
total cholesterol >4 mmol/Lhierarchical composite; interaction P = 0.016
1.75(1.51–2.03)
Subdistribution hazard ratio (95% CI)
SBP ≥130 mm Hg or diastolic BP ≥80 mm HgCV death, MI, stroke, or HF; interaction P = 0.003
0.86(0.61–1.21)
BP <130/80 mm HgCV death, MI, stroke, or HF; interaction P = 0.003
4.85(1.65–14.26)
participants with diabetesinteraction P = 0.054
0.53(0.24–1.15)
participants without diabetesinteraction P = 0.054
1.25(0.88–1.78)
Original publication
Identifying Patients With Prostate Cancer Who Benefit Most From Routine Cardiovascular Specialist Referral. JACC CardioOncol. Published 30 August 2026. doi:10.1016/j.jaccao.2026.08.001
Summarised from the published abstract; every number is checked against it