Cardio-oncology & otherCohort study
Imaging REASSESSment of embolic events before antibiotic discontinuation in infective endocarditis: REASSESS-IE study
- Prospective multicentre study
Authors' conclusion
Imaging reassessment of IE-related EEs before stopping antibiotics may lead to therapeutic modification in asymptomatic or clinically stable patients using a risk-stratified individualized imaging strategy guided by the endocarditis teams, rather than a uniform approach. Prospective studies are needed to define standardized imaging algorithms.
Study context
- Population
- Asymptomatic or clinically stable patients with definite or possible infective endocarditis (IE) complicated by embolic events (EEs), under antibiotic therapy (2013–2022)included patients with IE-related EEs, 700/1300 of the entire cohort had IE-related EEs
- Participants
- 554 participants
- Outcome
- Therapeutic impact: antibiotic modification and/or intervention
- Follow-up
- Before antibiotic discontinuation (median, 6 weeks)
Main finding
As reported in the abstract
Follow-up imaging performed
51% (n = 281/554)
Treatment modification among those imaged
5.7% (16/281)
Observational data: associations, not effects.
Secondary outcomes
All-cause mortality · in-hospital and 5-year
- In-hospital mortality
- 9.4%
- 5-year mortality
- 30.8%
- Haemodynamic instability and comorbidities associated with long-term mortality; only cardiac surgery associated with improved survival
- secondary endpoint
Embolic event characteristics
- cerebral EEs
- 49%
- extracerebral EEs
- 79%
- ischaemic stroke
- 42%
- splenic embolism
- 40%
Original publication
Imaging REASSESSment of embolic events before antibiotic discontinuation in infective endocarditis: REASSESS-IE study. Eur Heart J Cardiovasc Imaging. Published 9 September 2026. doi:10.1093/ehjci/jeag234
Summarised from the published abstract; every number is checked against it