Arrhythmias & electrophysiologyRandomised controlled trial
Immediate Ambulatory Electrocardiographic Monitoring in Syncope
- Randomised controlled trial
- open-label
- 45 hospitals in the UK
Authors' conclusion
Among patients with syncope that remained unexplained after evaluation in the emergency department, the use of 14-day ambulatory ECG monitoring did not result in significantly fewer patient-reported syncope episodes at 1 year than standard care.
Study context
- Population
- Adults with syncope unexplained after evaluation in the ED1,970 in primary analysis
- Participants
- 2,234 adults
- Comparison
- 14-day ambulatory electrocardiographic (ECG) monitoring vs standard care
- Interventionn = 1,123
- Standard caren = 1,111reference
- Primary endpoint
- Mean number of patient-reported episodes of syncope
- Follow-up
- 1 year
Primary result
As reported in the abstract
Incidence rate ratio
0.89
95% CI 0.68–1.18
P = 0.42
By group
Intervention vs Standard care
IRR 0.89 (95% CI 0.68–1.18); P = 0.42
Safety
| Outcome | Intervention | Standard care |
|---|---|---|
| Adverse events | ||
| Serious adverse events | 1 | 1 |
Original publication
Immediate Ambulatory Electrocardiographic Monitoring in Syncope. N Engl J Med. Published 30 August 2026. doi:10.1056/nejmoa2605812
Summarised from the published abstract; every number is checked against it