Immediate Versus Staged Complete Revascularization in Multivessel Disease and STEMI: A Meta-Analysis of Randomized Trials
Pooled result · All-cause mortalityResult — go to the resultHazard ratio 1.50 95% CI 1.02–2.21Authors' conclusion
In STEMI and multivessel disease, immediate complete revascularization may be associated with an increased risk of all-cause death at 1-year when compared with staged complete revascularization. The treatment effect on mortality should be interpreted cautiously because of the relatively low number of deaths across the 4 trials and the statistical fragility of the findings. The findings from this analysis do not support an immediate complete revascularization strategy in these patients.
Study context
- Population
- Patients with STEMI and multivessel disease
- Participants
- 2,651 patients4 randomized trials
- Comparison
- Immediate vs staged complete revascularization
- Outcome
- all-cause mortality
- Follow-up
- 1-year
Methodological detailsrandom-effects models with inverse-variance weighting
- Random-effects models with inverse-variance weighting
Pooled result
As reported in the abstract
Hazard ratio
1.50
95% CI 1.02–2.21
P = 0.04
Immediate complete revascularizationvs staged complete revascularization
HR 1.50 (95% CI 1.02–2.21); P = 0.04
Further pooled results
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Recurrent MI (protocol specified definitions including procedural MI)PI: 0.22-1.54; I2 = 0%; t2 = 0.034 | 0.58 (0.36–0.94) | P = 0.02 | |
| Spontaneous MIPI: 0.41-2.00; I2 = 0%; τ2 = 0.00 | 0.91 (0.55–1.48) | P = 0.90 | |
| 0.20.5125Hazard ratio (log scale) |
Cardiac death and unplanned revascularization
- Comparable between the treatment groups
Original publication
Immediate Versus Staged Complete Revascularization in Multivessel Disease and STEMI: A Meta-Analysis of Randomized Trials. JACC Cardiovasc Interv. Published 12 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →