Immediate Versus Staged Complete Revascularization in Multivessel Disease and STEMI
Pooled result · all-cause mortalityResult — go to the resultHazard ratio 1.50 95% CI 1.02–2.21- frequentist, pairwise meta-analysis
- random-effects models with inverse-variance weighting
+1 more
- random-effects models with inverse-variance weighting
Authors' conclusion
In STEMI and multivessel disease, immediate complete revascularization may be associated with an increased risk of all-cause death at 1-year when compared with staged complete revascularization. The treatment effect on mortality should be interpreted cautiously because of the relatively low number of deaths across the 4 trials and the statistical fragility of the findings. The findings from this analysis do not support an immediate complete revascularization strategy in these patients.
Study context
- Population
- Patients with STEMI and multivessel disease
- Participants
- 2,651 patients · 4 randomized trials
- Comparison
- immediate vs staged complete revascularization
- Outcome
- all-cause mortality
- Follow-up
- 1-year
Pooled result
all-cause mortality
Hazard ratio
1.50
95% CI 1.02–2.21
P = 0.04
immediate complete revascularization vs staged complete revascularization
HR 1.50 (95% CI 1.02–2.21); P = 0.04
As reported in the abstract
Further pooled results
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Recurrent MI (protocol specified definitions including procedural MI) · PI: 0.22-1.54; I2 = 0%; t2 = 0.034 | 0.58 (0.36–0.94) | P = 0.02 | |
| Spontaneous MI · PI: 0.41-2.00; I2 = 0%; τ2 = 0.00 | 0.91 (0.55–1.48) | P = 0.90 | |
| 0.20.5125Hazard ratio (log scale) |
Cardiac death and unplanned revascularization
- comparable between the treatment groups
Original publication
Immediate Versus Staged Complete Revascularization in Multivessel Disease and STEMI. JACC Cardiovasc Interv. Published 12 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it