Heart failure & cardiomyopathies
Immuno-Haemostatic Dysregulation in Heart Failure with Preserved Ejection Fraction
Authors' conclusion
Patients with HFpEF present with dysfunctional platelets, a procoagulant state and neutrophil activation.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF)
- Comparison
- HFpEF vs matched controls vs healthy reference cohort
- HFpEFn = 103
- Matched controlsn = 40reference
- Outcome
- Platelet function, coagulation and neutrophil activation
Methodological detailsage- and sex-matched controls
- Age- and sex-matched controls
Main finding
As reported in the abstract
Platelet function
Association of aberrant platelet activation and function with HFpEF, independent of comorbidities or medications (thrombus size, contraction, height; fully adjusted model)
<0.001; <0.001; <0.001
Observational data: associations, not effects.
Further findings
In vivo platelet activation marker β-TG
In vivo platelet activation marker CXCL4
- Neutrophil activation markers (higher in HFpEF) · HFpEF vs Matched controls · MPO
- P = 0.0152
- Neutrophil activation markers (higher in HFpEF) · HFpEF vs Matched controls · S100A8/A9
- P = 0.0041
- Coagulation (elevated in HFpEF, particularly without anticoagulant) · HFpEF vs Matched controls · plasma kallikrein
- P = 0.0415
- Coagulation (elevated in HFpEF, particularly without anticoagulant) · HFpEF vs Matched controls · FXIa:C1inh, anticoagulant users excluded
- P = 0.0110
- Coagulation (elevated in HFpEF, particularly without anticoagulant) · HFpEF vs Matched controls · FIXa:AT, anticoagulant users excluded
- P = 0.0095
- Coagulation (elevated in HFpEF, particularly without anticoagulant) — T:AT, anticoagulant users excluded (vs reference 4 μg/L)
- 4.46 μg/L
- Coagulation (elevated in HFpEF, particularly without anticoagulant) — D-dimer, anticoagulant users excluded (vs reference 0.5 mg/L)
- 0.65 mg/L
Endothelial markers ICAM-1 and VCAM-1
- Unaltered between groups
Original publication
Immuno-Haemostatic Dysregulation in Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 10 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →