Heart failure & cardiomyopathiesCohort study
Impact and prognostic implications of aortic stenosis across the heart failure spectrum: a cohort study
- retrospective cohort study
Authors' conclusion
AS is common in HF and is associated with substantially worse long-term outcomes across all HF subtypes, even at non-severe stages. The high mortality risk and frequent lack of intervention highlight major treatment gaps and underscore the need for prospective trials evaluating earlier intervention strategies.
Study context
- Population
- Patients with heart failure (HF) undergoing echocardiography between 2010 and 2020patients with HF undergoing echocardiography
- Participants
- 22,906 patients
- Exposure
- Increasing aortic stenosis (AS) severity compared with HF patients without AS
- Outcome
- event-free survival, defined as all-cause mortality or aortic valve replacement (AVR)
Main finding
As reported in the abstract
Each group vs HF patients without ASAdjusted hazard ratio (95% CI)
moderate AS
2.20(2.00–2.41)
LG AS
3.32(2.97–3.72)
severe AS
6.20(5.74–6.69)
Observational data: associations, not effects.
Further findings
| Outcome | HF patients without AS | moderate AS | LG AS | severe AS |
|---|---|---|---|---|
| Prevalence of AS grades in HF patients | Not reported in the abstract | 5.5% | 2.5% | 6.5% |
- Aortic valve replacement (AVR) in HF patients with severe AS · within 2 years
- 59.5% · 95% CI 57%–62%
Prevalence of AS grades in HF patients
- HF with preserved ejection fraction (HFpEF) the most common HF subtype across all AS grades
Original publication
Impact and prognostic implications of aortic stenosis across the heart failure spectrum: a cohort study. Heart. Published 21 January 2026. doi:10.1136/heartjnl-2025-326808
Summarised from the published abstract; every number is checked against it