Arrhythmias & electrophysiologyCohort study
Impact of atrial fibrillation diagnosis-to-ablation time on 24-month efficacy and safety outcomes in the Cryo Global Registry
- Prospective registry cohort study
- multicentre
- 121 centres in 37 countries
Authors' conclusion
CBA within 12 months from AF diagnosis resulted in higher freedom from AA recurrence and is associated with fewer safety events in a real-world evaluation.
Study context
- Population
- Patients with atrial fibrillation (AF) undergoing cryoballoon ablation in the Cryo Global Registry1,220 followed through 24 months
- Participants
- 3,447 patients
- Exposure
- Early vs late cryoballoon ablation
- Earlyn = 1,573
- Laten = 1,874reference
- Outcome
- Freedom from atrial arrhythmia recurrence
- Follow-up
- 24 months
Main finding
As reported in the abstract
Freedom from atrial arrhythmia (AA) recurrence
P < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (CI) | P value | |
|---|---|---|---|
| Cardioversion · 41% lower risk | 0.59 (0.42–0.83) | P < 0.01 | |
| 0.512Adjusted hazard ratio (log scale) |
Safety
Serious procedure-related adverse events
P = 0.045
Original publication
Impact of atrial fibrillation diagnosis-to-ablation time on 24-month efficacy and safety outcomes in the Cryo Global Registry. Europace. Published 21 January 2025. doi:10.1093/europace/euaf008
Summarised from the published abstract; every number is checked against it