Valvular & structural heart diseaseCohort study
Impact of Balloon-Expandable Transcatheter Aortic Valve Replacement (TAVR) Valve Deformation and Calcium Distribution on Outcomes in Bicuspid Aortic Valve
- Retrospective cohort study
- consecutive patients
Authors' conclusion
THV deformation post-TAVR was significantly linked to all-cause mortality in patients with BAVs. Annular and left ventricular outflow tract calcification correlated with increased risks for all-cause mortality and leaflet thrombosis.
Study context
- Population
- Patients with bicuspid aortic valves undergoing TAVR with balloon-expandable valves, with computed tomography (CT) 30 days post-TAVR
- Participants
- 229 patients
- Exposure
- Transcatheter heart valve (THV) underexpansion and/or eccentricity vs no THV deformation after TAVR
- Group 1n = 125reference
- Group 2n = 69
- Group 3n = 35
- Outcome
- All-cause mortality
- Follow-up
- 3 years
Main finding
As reported in the abstract
- Group 3 had higher all-cause mortality than the other groups
Observational data: associations, not effects.
Further findings
Hypoattenuated leaflet thickening · 30 days
- Highest risk in Group 3
Predictors of all-cause mortality and hypoattenuated leaflet thickening
- Annular and LV outflow tract calcification independent predictors (multivariate analysis)
All-cause mortality, type 1 BAV (subgroup) · 3 years
- Excessive calcification at the raphe and opposite leaflet associated with all-cause mortality
Original publication
Impact of Balloon-Expandable TAVR Valve Deformation and Calcium Distribution on Outcomes in Bicuspid Aortic Valve. JACC Cardiovasc Interv. Published 9 September 2024. doi:10.1016/j.jcin.2024.07.018
Summarised from the published abstract; every number is checked against it