Impact of baseline systolic blood pressure on blood pressure changes following renal denervation
Authors' conclusion
Baseline SBP was associated with 6-month SBP reductions after RDN in hypertensive patients.
Study context
- Population
- Patients with uncontrolled hypertension undergoing radiofrequency renal denervation (RDN), pooled from SPYRAL First-In-Human, SYMPLICITY HTN-3, SYMPLICITY HTN-Japan, SPYRAL HTN ON-MED and Global SYMPLICITY Registry DEFINEpooled from multiple clinical studies
- Participants
- 3,377 patients
- Outcome
- 6-month SBP change modelled against baseline SBP (linear regression)
- Follow-up
- 6 months
Methodological detailsmulticentre
- Multicentre
Pooled result
As reported in the abstract
Association of baseline SBP with 6-month SBP reduction
- Higher baseline systolic blood pressure (SBP) correlated with greater SBP reductions (P<0.0001), office SBP r2
- 0.21
- Higher baseline SBP correlated with greater SBP reductions (P<0.0001), 24h ambulatory SBP r2
- 0.13
- 6-month reduction at baseline office SBP 150 mmHg
- 4.2 mmHg
- 6-month reduction at baseline office SBP 160 mmHg
- 9.8 mmHg
- 6-month reduction at baseline office SBP 170 mmHg
- 15.4 mmHg
- 6-month reduction at baseline office SBP 180 mmHg
- 21.0 mmHg
Further pooled results
Office SBP decrease · 6 months
- Mean decrease (±SD), mmHg
- 16.3±24.0
- Baseline 171.8±20.5 mmHg
24h ambulatory SBP decrease · 6 months
- Mean decrease (±SD), mmHg
- 7.5±16.7
- Baseline 155.9±17.3 mmHg
Antihypertensive drug classes prescribed
- Baseline
- 4.4±1.5
- 6 months
- 4.3±1.5
- Baseline vs 6 months
- P < 0.0001
Original publication
Impact of baseline systolic blood pressure on blood pressure changes following renal denervation. EuroIntervention. Published 3 November 2025. doi:10.
Summarised from the published abstract; every number is checked against it