Arrhythmias & electrophysiology
Impact of Catheter Ablation on Arrhythmia Burden in Patients With Shock-Resistant Persistent Atrial Fibrillation
Authors' conclusion
Patient-tailored catheter ablation results in a significant reduction in ATA burden (off antiarrhythmic medication) in shock-resistant persistent AF patients using ICMs implanted 2-months pre-procedure.
Study context
- Population
- Patients with drug-resistant ongoing persistent atrial fibrillation (AF) and ≥1 previous failed cardioversion, first-time ablation
- Participants
- 60 patients
- Exposure
- Atrial tachyarrhythmia (ATA) burden before vs after catheter ablation
- Outcome
- Median ATA burden (ICM), off antiarrhythmic medication
- Follow-up
- Post-blanking
Methodological detailsimplantable cardiac monitor implanted 2 months pre-procedure, off antiarrhythmic medication, implantable cardiac monitor (ICM) recordings reviewed by 2 independent investigators
- Implantable cardiac monitor implanted 2 months pre-procedure
- Off antiarrhythmic medication
- ICM recordings reviewed by 2 independent investigators
Main finding
ATA burden
Median reduction
100%
95% CI 4%–100%
P < 0.001
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | After ablation | P value |
|---|---|---|
| ATA burden in patients with recurrent ATA | median 11.4% (95% CI 0.35%–99.7%) | P < 0.001 |
Recurrent ATA · 12-month follow-up
- Patients with recurrent ATA
- 27 (45%)
Quality of life
- Improved significantly from baseline, driven by lack of recurrence
Original publication
Impact of Catheter Ablation on Arrhythmia Burden in Patients With Shock-Resistant Persistent Atrial Fibrillation. JACC Clin Electrophysiol. Published 2 August 2023. doi:10.
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