Prevention & lipidsCohort study
Impact of clonal haematopoiesis on atherosclerotic cardiovascular disease according to low-density lipoprotein cholesterol levels in general population
- Prospective cohort study
Authors' conclusion
The presence of CHIP was significantly associated with the risk of ASCVD, promoting the early stage of atherosclerosis through synergy with high LDL cholesterol in the general population.
Study context
- Population
- Asymptomatic Korean adults aged 40–79 years, general population
- Participants
- 4,300 adults
- Exposure
- Clonal haematopoiesis of indeterminate potential (CHIP) carriers vs non-carriers
- CHIP carriersn = 363
- Outcome
- ASCVD
- Follow-up
- Median 4.7 years
Main finding
As reported in the abstract
Adjusted hazard ratio
2.49
95% CI 1.45–4.29
P < 0.001
Events by group
CHIP carriers vs Non-carriers
adjusted HR 2.49 (95% CI 1.45–4.29); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (95% CI) | P value | |
|---|---|---|---|
| ASCVD with high LDL-C (subgroup) | 6.20 (3.14–12.23) | P < 0.001 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
- Atherosclerotic cardiovascular disease (ASCVD) with high LDL-C (subgroup) — Synergism between CHIP and LDL-C (S-index)
- 4.94; 95% CI 1.08-22.53; P = 0.039
Coronary changes on serial coronary computed tomography angiography (CCTA)
- CHIP with high LDL-C: new measurable coronary atherosclerosis, mainly unstable plaque, in proximal lesions
Original publication
Impact of clonal haematopoiesis on atherosclerotic cardiovascular disease according to low-density lipoprotein cholesterol levels in general population. Eur J Prev Cardiol. Published 13 February 2024. doi:10.1093/eurjpc/zwae055
Summarised from the published abstract; every number is checked against it