Heart failure & cardiomyopathiesCohort study
Impact of Coronary Artery Disease in Women With Newly Diagnosed Heart Failure and Reduced Ejection Fraction
- Registry-based cohort study
- Western Denmark Heart Registry
Authors' conclusion
In patients with newly diagnosed HFrEF, the presence and extent of CAD has significantly greater prognostic impact among women than among men.
Study context
- Population
- Patients with newly diagnosed heart failure and reduced ejection fraction (HFrEF) referred for first-time coronary angiography891 women and 2,403 men
- Exposure
- Coronary artery disease (CAD) vs no CAD, women vs men
- Outcome
- All-cause mortality
- Follow-up
- 10 years
Main finding
As reported in the abstract
10-year all-cause mortality
Adjusted hazard ratio (95% CI)
Women without CAD vs Men without CAD
0.73(0.58–0.91)
Women with CAD vs Men with CAD
1.00(0.81–1.24)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Mortality by CAD extent (number of stenosed vessels) — Women with diffuse CAD vs Women without CAD | 1.61 (1.09–2.38) | |
| Mortality by CAD extent (number of stenosed vessels) — Women with 3-vessel disease vs Women without CAD | 2.01 (1.19–3.40) | |
| Mortality by CAD extent (number of stenosed vessels) — Men with 3-vessel disease vs Men without CAD | 1.51 (1.19–1.91) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- Mortality by CAD extent (number of stenosed vessels) — CAD extent associated with mortality in women
- P < 0.01
- Mortality by CAD extent (number of stenosed vessels) — CAD extent associated with mortality in men
- P < 0.01
Original publication
Impact of Coronary Artery Disease in Women With Newly Diagnosed Heart Failure and Reduced Ejection Fraction. JACC Heart Fail. Published 23 August 2023. doi:10.1016/j.jchf.2023.07.013
Summarised from the published abstract; every number is checked against it