Coronary disease & ACSResearch article
Impact of Coronary Microvascular Dysfunction on Patient-Reported Symptoms After Percutaneous Coronary Intervention (PCI)
- study
Authors' conclusion
CMD is present in approximately one-third of patients undergoing PCI and occurs with similar frequency in focal and diffuse CAD. CMD alone was not associated with residual angina. However, its clinical relevance varied according to the epicardial disease pattern: in focal CAD, concomitant CMD was associated with less symptomatic improvement after PCI, whereas in diffuse CAD, residual symptoms appeared to be driven predominantly by persistent epicardial disease.
Study context
- Population
- Patients with hemodynamically significant coronary artery disease (CAD) (fractional flow reserve ≤0.80) undergoing PCImean age 68.5 ± 10.1 years, 71% male
- Participants
- 201 patients
- Comparison
- Coronary microvascular dysfunction (CMD) vs no CMD; focal vs diffuse CAD
- CMDn = 75
Main finding
As reported in the abstract
CMD prevalence, focal vs diffuse CAD
- CMD present
- 75 (37.3%)
Further findings
| Outcome | CMD | Focal CAD | Diffuse CAD |
|---|---|---|---|
| SAQ summary score · baseline · without reaching statistical significance | 64.0 ± 25.3 | Not reported in the abstract | Not reported in the abstract |
| SAQ summary score · 1 year | 87.6 ± 16.0 | Not reported in the abstract | Not reported in the abstract |
- Seattle Angina Questionnaire (SAQ) summary score: no CMD 69.6 ± 21.0
- SAQ summary score: P = 0.09
- SAQ summary score: no CMD 89.4 ± 16.4
- SAQ summary score: P = 0.47
Residual angina, PPG × microvascular resistance reserve interaction
- patients with focal CAD and concomitant CMD had the highest burden of residual symptoms
- P for interaction = 0.015
Original publication
Impact of Coronary Microvascular Dysfunction on Patient-Reported Symptoms After PCI. JACC Adv. Published 13 July 2026. doi:10.1016/j.jacadv.2026.102946
Summarised from the published abstract; every number is checked against it