Prevention & lipidsCohort study
Impact of diabetes on risk of major adverse cardiovascular events associated with lipoprotein(a) levels in patients with established atherosclerotic cardiovascular disease
- Retrospective cohort study
Authors' conclusion
Among atherosclerotic patients with and without T2DM, elevated Lp(a) level was significantly associated with a higher risk of MACE.
Study context
- Population
- Patients with established atherosclerotic CVD, with and without T2DM, screened for Lp(a) 2000–20207,535 with T2DM
- Participants
- 25,826 patients
- Exposure
- Lp quintiles Q2–Q5 vs lowest quintile, in patients with and without T2DM
- Outcome
- MACE
Main finding
As reported in the abstract
MACE by Lp(a) quintile, T2DM and no T2DM
Hazard ratio (95% CI)
Q2 vs Q1T2DM
1.10(0.94–1.30)
Q3 vs Q1T2DM
0.98(0.83–1.16)
Q4 vs Q1T2DM
1.25(1.06–1.46)
Q5 vs Q1T2DM
1.29(1.10–1.51)
Q2 vs Q1no T2DM
0.99(0.88–1.12)
Q3 vs Q1no T2DM
1.10(0.98–1.23)
Q4 vs Q1no T2DM
1.01(0.90–1.13)
Q5 vs Q1no T2DM
1.13(1.01–1.27)
- Lp(a)-MACE association stronger with T2DM
- P < 0.001
- Total major adverse cardiovascular events (MACE) during 160 174 person-years
- 4836
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of diabetes on risk of major adverse cardiovascular events associated with lipoprotein(a) levels in patients with established atherosclerotic cardiovascular disease. Eur J Prev Cardiol. Published 11 March 2025. doi:10.1093/eurjpc/zwaf036
Summarised from the published abstract; every number is checked against it