Heart failure & cardiomyopathiesCohort study
Impact of Donor Left Ventricular Geometric Remodeling and Hypertrophy on Heart Acceptance and Recipient Survival
- Cohort study
- multicentre
Authors' conclusion
Classifying donor hearts using LV geometric remodeling patterns may reduce the number turned down for "hypertrophy" without compromising recipient survival.
Study context
- Population
- Brain-dead heart donors, US DHS (Donor Heart Study), February 2015 to May 20201,874 with nonacceptance surveys
- Participants
- 3,647 donors
- Exposure
- Donor left ventricular (LV) geometric remodeling patterns vs LV wall thickness >1.3 cm
- Outcome
- Prevalence of LV geometric remodeling patterns (ASE guidelines) and association with transplant acceptance and recipient mortality
- Follow-up
- 3 years
Main finding
As reported in the abstract
3-year recipient survival
Each group vs normal geometryAdjusted hazard ratio (95% CI)
Increased LV wall thickness
0.94(0.73–1.21)
Concentric remodeling
1.13(0.86–1.47)
Concentric hypertrophy
0.64(0.35–1.15)
- Concentric remodeling most common pattern
- 58.5%
Observational data: associations, not effects.
Further findings
| Outcome | Normal geometry | Concentric remodeling | Concentric hypertrophy | Increased LV wall thickness |
|---|---|---|---|---|
| Reclassification of hearts with LV wall thickness >1.3 cm | Not reported in the abstract | 52.1% | 43.8% | Not reported in the abstract |
| LV hypertrophy listed as reason for rejection (nonacceptance surveys) | 10.8% | 60.0% | Not reported in the abstract | Not reported in the abstract |
- LV hypertrophy listed as reason for rejection (nonacceptance surveys) — LV hypertrophy listed as reason for rejection
- 20.3%
- LV hypertrophy listed as reason for rejection (nonacceptance surveys): n = 1,874 nonacceptance surveys
Original publication
Impact of Donor Left Ventricular Geometric Remodeling and Hypertrophy on Heart Acceptance and Recipient Survival. JACC Heart Fail. Published 20 May 2026. doi:10.1016/j.jchf.2026.103150
Summarised from the published abstract; every number is checked against it