Prevention & lipidsCross-sectional study
Impact of elevated lipoprotein(a) on coronary artery disease phenotype and severity
- Cross-sectional study
- non-interventional
- single tertiary cardiology centre
Authors' conclusion
Elevated Lp(a) was associated with a more severe presentation of CAD.
Study context
- Population
- Patients aged ≥21 years undergoing angiography (October 2016-March 2018) at a tertiary cardiology centre with ≥1 Lp(a) measurement (LipidCardio)
- Participants
- 975 patients
- Exposure
- Elevated Lp vs normal Lp
- Outcome
- Coronary artery disease (CAD) severity by SYNTAX-I and Gensini scores and angiographic characteristics
Main finding
As reported in the abstract
CAD severity scores
Vessel(s) with lesions
P = 0.03
Diffusely narrowed vessels
P = 0.01
CTO lesions
| Outcome | Normal Lp(a) | Elevated Lp(a) | P value |
|---|---|---|---|
| Median SYNTAX-I | 3.0 | 5.5 | P = 0.01 |
| Median Gensini | 10.0 | 16.0 | P < 0.01 |
- Elevated Lp(a) vs Normal Lp(a): P < 0.01 — chronic total occlusion lesions
Observational data: associations, not effects.
Further findings
Prior CAD, prior coronary revascularization, prior CABG
Prior CAD
P < 0.01
Prior coronary revascularization
P = 0.01
Prior CABG
P < 0.01
Baseline Lp(a) distribution
- Median baseline Lp(a)
- 19.3 nmol/L
- < 65 nmol/L
- 72.9%
- ≥100 nmol/L
- 21.0%
- ≥125 nmol/L
- 17.2%
- ≥150 nmol/L
- 12.9%
Original publication
Impact of elevated lipoprotein(a) on coronary artery disease phenotype and severity. Eur J Prev Cardiol. Published 13 February 2024. doi:10.1093/eurjpc/zwae007
Summarised from the published abstract; every number is checked against it