Impact of Female Sex on Cardiogenic Shock Outcomes

doi:10.1016/j.jchf.2023.09.025

Acute cardiac care & resuscitationCohort study

Impact of Female Sex on Cardiogenic Shock Outcomes

JACC Heart FailPublished 6 Nov 2023

Retrospective cohort study
propensity-score matched

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Authors' conclusion

Women with HF-CS had worse outcomes and more vascular complications than men with HF-CS.

Study context

Population: Patients with cardiogenic shock (AMI-CS or HF-CS) in the Cardiogenic Shock Working Group
Participants: 5,083 patients

Exposure: Women vs men with cardiogenic shock
Womenn = 1,522
Outcome: Survival at discharge
Follow-up: Discharge

Main finding

As reported in the abstract

Survival at discharge, HF-CS (before PSM)

Women69.9%

Men74.4%

P = 0.009

Observational data: associations, not effects.

Further findings

AMI-CS

P = 0.03

Women30%

Men29.1%

De novo HF-CS

P < 0.001

Women26.2%

Men19.3%

Maximum SCAI stage E, HF-CS (before PSM)

P = 0.04

Women26%

Men21%

Pulmonary artery catheterization

P < 0.001

Women52.9%

Men54.6%

Heart transplantation

P < 0.001

Women6.5%

Men10.3%

LV assist device implantation

P = 0.01

Women7.8%

Men10%

Safety

Vascular complications (all CS etiologies)

P < 0.001

Women8.8%

Men5.7%

Bleeding

P = 0.01

Women7.1%

Men5.2%

Limb ischemia

P = 0.001

Women6.8%

Men4.5%

Vascular complications after PSM · matched cohort

P = 0.06

Women10.4%

Men7.4%

Original publication

Impact of Female Sex on Cardiogenic Shock Outcomes. JACC Heart Fail. Published 6 November 2023. doi:10.1016/j.jchf.2023.09.025

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Summarised from the published abstract; every number is checked against it