Impact of Gender-Affirming Hormonal Therapy on Cardiovascular Risk Factors in Transgender Health: An Updated Meta-Analysis
Authors' conclusion
GAHT affects lipid profiles in transgender patients
Study context
- Population
- Transgender individuals before and after gender-affirming hormone therapy12 observational studies · 12 RCTs
- Participants
- 1,241 vs 992
- Comparison
- Post-GAHT vs pre-GAHT
- Transmasculine (TM)n = 1,241
- Transfeminine (TF)n = 992
- Outcome
- Mean difference in lipid profile change, pre- vs post-GAHT
Pooled result
As reported in the abstract
Lipid profile change vs baseline · mean follow-up 28 months (TM), 39 months (TF)
- TM: significant increase in LDL, TG and total cholesterol; HDL decreased
- TF: significant increase in TG
Original publication
Impact of Gender-Affirming Hormonal Therapy on Cardiovascular Risk Factors in Transgender Health: An Updated Meta-Analysis. JACC Adv. Published 9 September 2024. doi:10.
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