Prevention & lipidsMeta-analysis
Impact of genetic risk information for cardiovascular disease on behavioural changes, psychological responses and risk factor modification: a systematic review
- Systematic review of randomised controlled trials
- narrative synthesis
- JBI methodology
- PRISMA 2020
Authors' conclusion
Genetic CVD risk information has limited effects on clinical outcomes and psychological factors, despite its potential to encourage some health behaviour changes.
Study context
- Population
- Participants given genetic cardiovascular disease (CVD) risk information11 studies
- Comparison
- Genetic CVD risk information vs no genetic risk information
- Outcome
- Health behaviours, psychological outcomes and risk factors
Pooled result
As reported in the abstract
- Modest improvements in dietary behaviour
- Inconclusive effects on physical activity and medication adherence
- Minimal changes in psychological outcomes, incl. slight decrease in depression
- Limited impact on traditional risk factors (SBP, total cholesterol)
- Bias across all studies
Original publication
Impact of genetic risk information for cardiovascular disease on behavioural changes, psychological responses and risk factor modification: a systematic review. Eur J Prev Cardiol. Published 4 November 2024. doi:10.1093/eurjpc/zwae362
Summarised from the published abstract; every number is checked against it