Prevention & lipidsCohort study
Impact of hypertriglyceridaemia on cardiovascular mortality according to low-density lipoprotein cholesterol in a 15.6-million population
- Cohort study
- nationwide health insurance database
- Cox models adjusted for confounders
Authors' conclusion
Hypertriglyceridaemia independently raises CVD mortality with lingering risks in young and older individuals with low LDL-C levels
Study context
- Population
- Adults aged 18–99 undergoing routine health examinations, Korean National Health Insurance Service database105,174 cardiovascular disease (CVD) deaths
- Participants
- 15,672,028 adults
- Exposure
- Triglyceride (TG) levels
- Outcome
- CVD mortality
- Follow-up
- Mean 8.8 years
Main finding
As reported in the abstract
CVD mortality per two-fold increase in TG · mean 8.8 years
Overall CVD mortality
1.10-fold
Ischaemic heart disease (IHD) mortality
1.22-fold
Acute MI mortality
1.24-fold
Ischaemic stroke mortality
1.10-fold
Observational data: associations, not effects.
Further findings
CVD mortality per two-fold higher TG, low-density lipoprotein cholesterol (LDL-C) < 100 mg/dL (subgroup)
- Overall CVD mortality
- 1.05-fold
- IHD mortality
- 1.12-fold
- Acute MI mortality
- 1.15-fold
- Ischaemic stroke mortality
- 1.05-fold
TG–mortality association by age (subgroup)
- Stronger associations with overall CVD, IHD and acute myocardial infarction (AMI) mortality in ages 18-44 than in older population
Original publication
Impact of hypertriglyceridaemia on cardiovascular mortality according to low-density lipoprotein cholesterol in a 15.6-million population. Eur J Prev Cardiol. Published 18 October 2023. doi:10.1093/eurjpc/zwad330
Summarised from the published abstract; every number is checked against it