Heart failure & cardiomyopathiesMechanistic study
Impact of Interventricular Interaction on Ventricular Function
- Mechanistic study
Authors' conclusion
Interventricular interactions resulted in improved RV compliance, diminished afterload, and did not reduce RV contractility.
Study context
- Population
- Clinically stable HeartMate3 LVAD recipients
- Participants
- 20 recipients
- Comparison
- High vs low LVAD speed during ramp tests
Main finding
As reported in the abstract
RV pressure-volume loop measures
| Group | Indexed right ventricular (RV) end-diastolic volume | RV end-systolic pressure | Effective arterial elastance |
|---|---|---|---|
| Low speed | 72.28 ± 15.07 mL | 31.58 ± 9.75 mL | 0.65 ± 0.43 mm Hg/mL |
| High speed | 75.95 ± 16.90 | 29.58 ± 9.41 mL | 0.54 ± 0.33 mm Hg/mL |
- High speed vs Low speed: P = 0.04 — indexed RV end-diastolic volume
- High speed vs Low speed: P = 0.02 — RV end-systolic pressure
- High speed vs Low speed: P = 0.02 — effective arterial elastance
Original publication
Impact of Interventricular Interaction on Ventricular Function. JACC Heart Fail. Published 10 January 2024. doi:10.1016/j.jchf.2023.12.001
Summarised from the published abstract; every number is checked against it