Coronary disease & ACSCohort study
Impact of Intravascular Ultrasound (IVUS) Guidance on Clinical and Procedural Outcomes in Intracoronary Brachytherapy
- retrospective analysis
Authors' conclusion
IVUS-guided ICBT for ISR was safe but was not independently associated with improved long-term outcomes.
Study context
- Population
- Patients undergoing intravascular brachytherapy (ICBT) for in-stent restenosis (ISR) between 2016 and 2024132/221 [59.7%] IVUS-guided
- Participants
- 221 patients
- Exposure
- Patients were stratified according IVUS use during the procedure
- IVUSn = 132
- non-IVUSn = 89
- Outcome
- target lesion revascularization
- Follow-up
- At
Main finding
As reported in the abstract
Hazard ratio
1.68
95% CI 1.05–2.68
P = 0.03
IVUS
HR 1.68 (95% CI 1.05–2.68); P = 0.03
Observational data: associations, not effects.
Secondary outcomes
Vessel diameter
Advanced lesion preparation
All-cause mortality · median follow-up of 717.9 ± 46.1 days · more frequent in the non-IVUS group
Brachytherapy dwell time
- Vessel diameter: P < 0.001
- Advanced lesion preparation: P < 0.001
- Brachytherapy dwell time: P < 0.001
- All-cause mortality: P = 0.03
Safety
Postprocedural myocardial infarction · median follow-up of 717.9 ± 46.1 days · more frequent in the non-IVUS group
- Postprocedural myocardial infarction: P = 0.005
Original publication
Impact of IVUS Guidance on Clinical and Procedural Outcomes in Intracoronary Brachytherapy. JACC Adv. Published 11 June 2026. doi:10.1016/j.jacadv.2026.102890
Summarised from the published abstract; every number is checked against it