Arrhythmias & electrophysiologyCohort study
Impact of left atrial appendage flow velocity on thrombus resolution and clinical outcomes in patients with atrial fibrillation and silent left atrial thrombi: insights from the LAT study
- Prospective cohort study
- multicentre
- observational
Authors' conclusion
Failed LA thrombus resolution was not rare in patients with AF and silent LA thrombi. Reduced LAAFV was associated with failed LA thrombus resolution and adverse clinical outcomes.
Study context
- Population
- Patients with atrial fibrillation (AF) and silent left atrial (LA) thrombi detected by transoesophageal echocardiography (TEE), with baseline LAAFV available297 with silent LA thrombi of 17,436 TEE
- Participants
- 169 patients
- Exposure
- Reduced LAAFV vs preserved LAAFV
- Outcome
- LA thrombus resolution
- Follow-up
- 1 year
Main finding
As reported in the abstract
Odds ratio
2.72
95% CI 1.22–6.09
P = 0.015
Reduced LAAFV vs Preserved LAAFV
OR 2.72 (95% CI 1.22–6.09); P = 0.015
- Thrombus resolution confirmed
- 130 (76.9%)
- Time to resolution
- 76 (34-138) days
- Residual LA thrombi
- 26
- Thromboembolisms
- 8
- Surgical removal
- 5
- Baseline LAAFV, failed vs successful resolution
- 18.0 [15.8-22.0] vs. 22.2 [17.0-35.0], P = 0.003
- AUC of LAAFV for failed resolution
- 0.659; P = 0.001
Observational data: associations, not effects.
Further findings
Ischaemic stroke/systemic embolism, major bleeding or all-cause death
log-rank P = 0.005
OAC use
- Baseline to final follow-up
- 85.7% to 97.0% (P < 0.001)
Original publication
Impact of left atrial appendage flow velocity on thrombus resolution and clinical outcomes in patients with atrial fibrillation and silent left atrial thrombi: insights from the LAT study. Europace. Published 1 May 2024. doi:10.1093/europace/euae120
Summarised from the published abstract; every number is checked against it