Valvular & structural heart diseaseCohort study
Impact of Left Atrial Strain on Severe Mitral Regurgitation Due to Mitral Annular Calcification
- retrospective, single-center cohort study
Authors' conclusion
LASr is associated with all-cause mortality in patients with isolated severe MR due to MAC and can serve as a valuable prognostic imaging marker for risk stratification. MV intervention improves prognosis across the spectrum of LASr.
Study context
- Population
- Patients with isolated severe mitral regurgitation (MR) due to mitral annular calcification (MAC)patients with isolated severe MR due to MAC identified between January 2010 and August 2023
- Participants
- 128 patients
- Exposure
- The cohort was stratified by the median reservoir left atrial strain (LAS).
- Mitral valve (MV) interventionn = 45/128
- conservative managementn = 83/128
- Outcome
- all-cause mortality
- Follow-up
- Median 134 days (IQR: 33-1,812 days)
Main finding
As reported in the abstract
Hazard ratio (95% CI)
LASr (per worsening)multivariate Cox analysis; mortality risk increased as LASr worsened
1.054(1.002–1.109)
MV interventionmultivariate Cox analysis; MV intervention improved prognosis
0.173(0.075–0.397)
Per worsening, as printed
- Patients died during follow-up
- 63/128
- Patients with LASr ≤13.6% had significantly poorer outcomes
- P = 0.031
- MV intervention improved survival across the spectrum of LASr
- P < 0.05
Observational data: associations, not effects.
Further findings
Baseline characteristics
- Median age (IQR: 71-88)
- 81 years
- Females
- 93/128 patients (72.7%)
Original publication
Impact of Left Atrial Strain on Severe Mitral Regurgitation Due to Mitral Annular Calcification. JACC Adv. Published 22 January 2026. doi:10.1016/j.jacadv.2025.102568
Summarised from the published abstract; every number is checked against it