Valvular & structural heart diseaseCohort study
Impact of maintaining mild mitral regurgitation beyond 1 year after mitral transcatheter edge-to-edge repair
- multi-centre registry-based analysis
Authors' conclusion
Maintaining MR within mild at 1-year post-M-TEER is associated with favourable cardiac reverse remodelling and improved clinical prognosis. These findings underscore the importance of long-term MR surveillance and its implications for outcome optimization following M-TEER.
Study context
- Population
- Patients who achieved mild mitral regurgitation (MR) at discharge following mitral transcatheter edge-to-edge repair (M-TEER)patients who achieved mild MR at discharge following M-TEER
- Participants
- 1,865 patients
- Exposure
- stable MR vs worsening MR at 1 year
Main finding
As reported in the abstract
Worsening MR occurred in
28.4%
Observational data: associations, not effects.
Further findings
LA reverse remodelling · baseline to 1 year
LV reverse remodelling · baseline to 1 year
Improvement in TR (≥ Grade 1) · baseline to 1 year
Adverse clinical outcomes (all-cause mortality and heart failure hospitalization) · beyond 1 year after M-TEER up to 2 years
| Comparison | hazard ratio (95% CI) | P value | |
|---|---|---|---|
| worsening MR | 2.02 (1.26–3.23) | P = 0.003 | |
| 0.20.5125Hazard ratio (log scale) |
- Left atrial (LA) reverse remodelling: P < .001
- Left ventricular (LV) reverse remodelling: P < .001
- Improvement in tricuspid regurgitation (TR) (≥ Grade 1): P < .001
- Adverse clinical outcomes (all-cause mortality and heart failure hospitalization): independently associated with increased risk; comparator not named
Original publication
Summarised from the published abstract; every number is checked against it