Cohort study
Impact of Moderate Aortic Stenosis in Patients With Heart Failure With Reduced Ejection Fraction
- Retrospective cohort study
- propensity-score matched
Authors' conclusion
In patients with HFrEF, moderate AS is associated with increased rates of HF hospitalization and mortality.
Study context
- Population
- Patients with heart failure with reduced ejection fraction (HFrEF) (left ventricular ejection fraction (LVEF) <50%)
- Participants
- 9,133 patients
- Exposure
- Moderate aortic stenosis (AS) vs no AS and severe AS
- Moderate ASn = 374
- Severe ASn = 362
- Outcome
- Composite of:
- All-cause mortality
- HF hospitalization
- Follow-up
- Median 3.1 years
Main finding
As reported in the abstract
Hazard ratio
1.24
95% CI 1.04–1.49
P = 0.01
By group
Moderate AS vs No AS
HR 1.24 (95% CI 1.04–1.49); P = 0.01
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | P value | |
|---|---|---|---|
| Survival with AVR · improved survival | 0.60 (0.36–0.99) | P < 0.05 | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | No AS | Moderate AS | Severe AS | Estimate | P value |
|---|---|---|---|---|---|
| HF hospitalization | Not reported in the abstract | 43.6% | 36.2% | P < 0.05 |
Heart failure (HF) hospitalization
- Severe AS more likely to undergo aortic valve replacement (AVR) during follow-up
Days alive outside hospital (matched cohort)
- Fewer days alive outside hospital with moderate AS
- P < 0.0001
- matched cohort
Original publication
Impact of Moderate Aortic Stenosis in Patients With Heart Failure With Reduced Ejection Fraction. J Am Coll Cardiol. Published 4 April 2023. doi:10.1016/j.jacc.2023.01.032
Summarised from the published abstract; every number is checked against it