Impact of outcome definitions on cardiovascular risk prediction in a contemporary primary prevention population
Authors' conclusion
ASCVD accounts for just over half of all preventable first cardiovascular events and even fewer first and recurrent cardiovascular events in contemporary practice.
Study context
- Population
- Ontario residents alive 1 January 2008, aged 30–99 years, with no prior cardiovascular disease (CVD)
- Participants
- 7,496 165 participants
- Exposure
- Atherosclerotic cardiovascular disease (ASCVD) vs global CVD outcome definitions
- Outcome
- Incidence of ASCVD and change in incidence when incorporating additional CV endpoints
- Follow-up
- 11 years
Methodological detailspopulation-level database
- Population-level database
Main finding
As reported in the abstract
Incident first CV event · 11 years
- Most common additional first manifestations: Heart failure (HF)
- 12.0%
- Most common additional first manifestations: coronary revascularization
- 12.7%
Observational data: associations, not effects.
Further findings
First and recurrent CV events
- First and recurrent CV events — Proportion of recurrent HF events
- 13.8%
- First and recurrent CV events — Proportion of recurrent coronary revascularization events
- 23.2%
Original publication
Impact of outcome definitions on cardiovascular risk prediction in a contemporary primary prevention population. Eur Heart J Qual Care Clin Outcomes. Published 29 July 2022. doi:10.
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