Coronary disease & ACSMeta-analysis
Impact of Post-PCI Fractional Flow Reserve (FFR) Stratified by Coronary Artery
- Systematic review and individual patient-level data meta-analysis of randomised trials and observational studies
- random-effects meta-analysis
Authors' conclusion
The LAD is associated with a lower post-PCI FFR than non-LAD arteries, emphasizing the importance of interpreting post-PCI FFR on a vessel-specific basis. Although a higher post-PCI FFR was associated with improved prognosis, its predictive capacity for events differs between the LAD and non-LAD arteries, being poor in the LAD and moderate in the non-LAD vessels.
Study context
- Population
- Patients with protocol-recommended post-PCI FFR assessment
- Participants
- 2,760 patients · 9 studies
- Comparison
- Post-PCI FFR in left anterior descending (LAD) vs non-LAD arteries
- Outcome
- Predictive capacity of post-PCI FFR for TVF (cardiac death, target vessel MI, clinically driven target vessel revascularization), by coronary artery
Pooled result
As reported in the abstract
Predictive capacity for TVF
| Group | AUC |
|---|---|
| LAD | 0.52 (95% CI: 0.47-0.58) |
| non-LAD | 0.66 (95% CI: 0.59-0.73) |
- LAD vs non-LAD: P = 0.005 — poor in LAD, moderate in non-LAD
Further pooled results
Weighted mean
| Outcome | LAD | non-LAD | P value |
|---|---|---|---|
| Post-PCI FFR by vessel | 0.86 (95% CI 0.85–0.88) | 0.93 (95% CI 0.91–0.94) | P < 0.001 |
- Post-PCI FFR by vessel — Overall weighted mean post-PCI FFR
- 0.89 (95% CI: 0.87-0.90)
Original publication
Impact of Post-PCI FFR Stratified by Coronary Artery. JACC Cardiovasc Interv. Published 9 October 2023. doi:10.1016/j.jcin.2023.08.018
Summarised from the published abstract; every number is checked against it