Heart failure & cardiomyopathiesCohort study
Impact of Pregnancy on Mortality in Dilated Cardiomyopathy: Immediate and 12-Month Postpartum Outcomes: Data From the InCor Pregnancy and Heart Disease Registry
- Prospective cohort
Authors' conclusion
Pregnancy in women with DCM was associated with high morbidity and late mortality. Reduced left ventricular ejection fraction and a history of thromboembolism were independent predictors of maternal death.
Study context
- Population
- Pregnant women with confirmed dilated cardiomyopathy (DCM) enrolled in the InCor Pregnancy and Heart Disease Registry (2013–2023)with DCM, among 983 registry patients · peripartum 32 · idiopathic 21 · myocarditis 15 · Chagas disease 11 · others 11
- Participants
- 90 women
Main finding
As reported in the abstract
Maternal complications
during pregnancy
51.1%
early postpartum period (up to 6 weeks after delivery)
36.0%
late postpartum period (from 6 weeks to 12 months after delivery)
38.6%
Observational data: associations, not effects.
Further findings
Maternal deaths · postpartum
- maternal deaths
- 9
- maternal deaths, %
- 10%
- mean time to death
- 8.8±3.1 months
- all occurred postpartum, mostly due to heart failure
Obstetric/fetal outcomes
- Cesarean section
- 75%
- fetal loss
- 10%
- prematurity
- 33.8%
- Mean birth weight
- 2606 g
Left ventricular ejection fraction
- at diagnosis
- 32%
- during pregnancy
- 39%
- at 12 months
- 42%
Independent predictors of death
- Lower left ventricular ejection fraction, odds ratio
- 0.87; P =0.006
- prior thromboembolism, odds ratio
- 15.5; P =0.017
- logistic regression
Original publication
Impact of Pregnancy on Mortality in Dilated Cardiomyopathy: Immediate and 12-Month Postpartum Outcomes: Data From the InCor Pregnancy and Heart Disease Registry. Circ Heart Fail. Published 6 January 2026. doi:10.1161/circheartfailure.125.013656
Summarised from the published abstract; every number is checked against it