Heart failure & cardiomyopathies
Impact of Prior Exercise Practice on Disease Characteristics in Desmoplakin-Related Arrhythmogenic Left Ventricular Cardiomyopathy
Authors' conclusion
Prior exercise intensity, duration, and cumulated lifetime dose were not associated with an increased risk of developing an ALVC phenotype at the time of diagnosis in DSP variant carriers.
Study context
- Population
- Patients with desmoplakin (DSP) pathogenic or likely pathogenic variant, interviewed about their exercise practice before genetic or disease diagnosismean age 39 ± 19 years, 49% female
- Participants
- 85 patients
- Exposure
- association of high-intensity (HI) and long duration (LD) exercise practice with the risk of arrhythmogenic left ventricular cardiomyopathy (ALVC) phenotype occurrence at diagnosis
Main finding
As reported in the abstract
Prior exercise practice · before genetic or disease diagnosis
Practiced HI exercise
69%
Practiced LD exercise
66%
Observational data: associations, not effects.
Further findings
ALVC phenotype at time of diagnosis
- ALVC phenotype at time of diagnosis: No HI exercise 65%
- ALVC phenotype at time of diagnosis: No LD exercise 69%
- ALVC phenotype at time of diagnosis: HI vs no HI P = 0.60
- ALVC phenotype at time of diagnosis: LD vs no LD P = 0.95
Distribution of prior calculated exercise dose, with vs without ALVC phenotype at diagnosis
- Not different
- P = 0.57
Original publication
Impact of Prior Exercise Practice on Disease Characteristics in Desmoplakin-Related Arrhythmogenic Left Ventricular Cardiomyopathy. JACC Clin Electrophysiol. Published 3 July 2025. doi:10.
Summarised from the published abstract; every number is checked against it