Arrhythmias & electrophysiologyCohort study
Impact of pulsed field ablation on ganglionated plexi function in atrial fibrillation
- prospective cohort study
- consecutive patients
Authors' conclusion
Endocardial PFA does not consistently abolish LA GP function despite lesion delivery at overlapping sites. RF ablation reliably eliminates GP-mediated AVD. These findings support the cardioselective nature of PFA and provide a mechanistic rationale for the prospective evaluation of adjunctive GP ablation following PFA-based PVI strategies.
Study context
- Population
- Patients with persistent atrial fibrillation undergoing first-time pulsed field ablation (PFA)patients enrolled
- Participants
- 10 patients
- Exposure
- Left atrial (LA) GP function at baseline, after PFA, and after targeted radiofrequency (RF) ablation
Main finding
As reported in the abstract
sites tested meeting AVD-GP criteria
118 of 591 sites tested (20.0%)
AVD-GP sites per patient
11.8 ± 7.8 per patient
AVD-GP sites at pulmonary vein ostia
23 (19.5%)
Observational data: associations, not effects.
Further findings
Transient atrioventricular delay (AVD) during PFA application
- patients with transient AVD
- 4 of 10 patients (40%)
Persistent AVD response in segments with AVD-GP sites overlying PFA-treated regions
- segments with persistent AVD response
- 16 of 21 segments
- segments/patient
- 2.0 ± 1.1 segments/patient
AVD response at previously active AVD-GP sites · after targeted RF ablation
- no previously active AVD-GP sites showed AVD response
Baseline characteristics
- age
- 61.9 ± 7.1 years
- female
- 3 female [30%]
Original publication
Summarised from the published abstract; every number is checked against it