Heart failure & cardiomyopathiesCohort study
Impact of rate-pressure product correction of myocardial blood flow on the prognostic relevance in patients with heart failure
- prospective cohort
Authors' conclusion
Uncorrected rest MBF and MPR by QP-CMR are independently predictive of adverse outcomes in patients with HF. RPP correction changes MBF and MPR values and attenuates their predictive value.
Study context
- Population
- Patients with heart failure (HF) undergoing quantitative perfusion cardiac magnetic resonance (QP-CMR), and healthy volunteerspatients with HF 641 · healthy volunteers 184
- Participants
- 641 vs 184
- Exposure
- Rate-pressure product (RPP)-corrected vs uncorrected rest myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) for prognosis
- patients with HFn = 641
- healthy volunteersn = 184
- Outcome
- Composite of:
- Heart failure hospitalization (HFH)
- All-cause mortality
- Follow-up
- Median 3.5 years
Main finding
As reported in the abstract
Estimate (95% CI)P value
Rest MBFuncorr
adjusted hazard ratio 3.97 per 1 mL/g/min increase(1.93–8.16)
P < 0.001MPRuncorr
adjusted hazard ratio 0.74 per 1-unit increase(0.57–0.95)
P = 0.024Each row per its own increment, as printed
- Events
- 101
- Deaths
- 55
- Heart failure hospitalization (HFH)
- 46
Observational data: associations, not effects.
Further findings
Effect of RPP correction on rest MBF and MPR
- RPP correction increased rest MBF and decreased MPR to a greater extent in healthy volunteers than in patients
Event-free survival (Kaplan-Meier)
- rest MBFuncorr
- P = 0.005
- MPRuncorr
- P < 0.001
- MPRcorr
- P = 0.044
- rest MBFcorr
- P = 0.076
Original publication
Impact of rate-pressure product correction of myocardial blood flow on the prognostic relevance in patients with heart failure. Eur Heart J Cardiovasc Imaging. Published 24 July 2026. doi:10.1093/ehjci/jeag193
Summarised from the published abstract; every number is checked against it