Coronary disease & ACSSecondary analysis
Impact of Revascularization Completeness on Cardiovascular Outcomes in STEMI With Multivessel Disease
- exploratory post hoc analysis of the COMPLETE trial
- substudy of the COMPLETE trial
- stratified Cox proportional hazards model
- core laboratory-derived modified residual SYNTAX score (R′SS)
Authors' conclusion
This exploratory analysis of the COMPLETE trial suggests that the benefit of a complete revascularization strategy in patients with ST-segment-elevation myocardial infarction and multivessel disease may be related to the extent of anatomic completeness of revascularization.
Study context
- Population
- Patients with ST-segment-elevation myocardial infarction and multivessel diseaseCOMPLETE trial
- Participants
- 3,738 patients
- Comparison
- Degree of anatomic completeness of revascularization (R′SS=0 or R′SS>0) vs culprit-only percutaneous coronary intervention (PCI) arm as reference
- Primary endpoint
- First coprimary outcome: composite of cardiovascular death or new myocardial infarction
Primary result
As reported in the abstract
Each group vs culprit lesion-only PCIAdjusted hazard ratio (95% CI)
R′SS=0
0.61(0.47–0.78)
R′SS>0
1.01(0.61–1.67)
Further findings
| Outcome | R′SS=0 | R′SS>0 | culprit lesion-only PCI |
|---|---|---|---|
| Revascularization completeness among patients randomized to complete revascularization | 90% | 10% | Not reported in the abstract |
Second coprimary outcome: composite of cardiovascular death, new myocardial infarction, or ischemia-driven revascularization
- A similar result was observed for the second coprimary outcome
Original publication
Impact of Revascularization Completeness on Cardiovascular Outcomes in STEMI With Multivessel Disease. Circ Cardiovasc Interv. Published 3 June 2026. doi:10.1161/circinterventions.126.016515
Summarised from the published abstract; every number is checked against it