Cohort study
Impact of Right Ventricular Pacing in Patients With Transcatheter Aortic Valve Replacement (TAVR) Undergoing Permanent Pacemaker Implantation
- Registry study
- international multicentre
- multivariable adjustment
Authors' conclusion
In TAVR patients undergoing permanent pacemaker implantation, a high percentage of right VP at follow-up is associated with an increased risk for cardiovascular death and HF hospitalization.
Study context
- Population
- Consecutive TAVR patients with permanent pacemaker implantation for conduction disturbances within 30 days after the procedure
- Participants
- 377 patients
- Exposure
- Ventricular pacing (VP) ≥40% vs VP <40%
- VP ≥40%n = 219
- VP <40%n = 158reference
- Outcome
- CV mortality or hospitalization for heart failure (HF)
Main finding
CV mortality or HF hospitalization
Hazard ratio
2.76
95% CI 1.39–5.51
P = 0.004
VP ≥40% vs VP <40%
HR 2.76 (95% CI 1.39–5.51); P = 0.004
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| First HF hospitalization | 3.37 (1.50–7.54) | P = 0.003 | |
| CV death | 3.77 (1.02–13.88) | P = 0.04 | |
| All-cause death · not significantly different | 2.17 (0.80–5.90) | P = 0.13 | |
| 0.050.21520Hazard ratio (log scale) |
NYHA functional class · 1 year and last available follow-up
- Higher NYHA class with VP ≥40% at 1 year
- P = 0.009
- Higher NYHA class with VP ≥40% at last available follow-up
- P = 0.04
LVEF on echocardiography · 1 year
- Nonsignificant LVEF reduction with VP ≥40%
- P = 0.18
- Significant LVEF improvement with VP <40%
- P = 0.009
Original publication
Impact of Right Ventricular Pacing in Patients With TAVR Undergoing Permanent Pacemaker Implantation. JACC Cardiovasc Interv. Published 8 May 2023. doi:10.1016/j.jcin.2023.02.003
Summarised from the published abstract; every number is checked against it